Paroxysmal cold hemoglobinuria with acute renal failure

Hemolysis-induced acute renal failure in paroxysmal nocturnal hemoglobinuria.

Paroxysmal nocturnal hemoglobinuria with acute leukemia.

T HE OCCURENCE of impaired marrow function in paroxysmal nocturnal hemoglobinuria (PNH) has long been recognized. A smaller group of patients, with an initial diagnosis of aplastic anemia, have been noted to develop signs of PNH during the course of their illness.1 Such persons have been said to have “the aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome.”2 Also evident, in some case...

Renal involvement in paroxysmal nocturnal hemoglobinuria.

Renal involvement in paroxysmal nocturnal hemoglobinuria (PNH) is not usually apparent but in cases with clinical involvement varies from reversible acute dysfunction to chronic irreversible damage. Early diagnosis and treatment is crucial to prevent disease progression and irreversible chronic kidney disease (CKD). The ultimate outcome of CKD in many patients is the need for renal replacement ...

Renal Manifestations in Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired chronic disorder characterized by a triad of clinical features - hemolytic anemia, pancytopenia, and thrombosis. Not many reports of renal involvement in PNH are available in literature. We present a case series of PNH with renal involvement. We present the data of PNH patients who attended to Departments of General Medicine and Nephrolog...

Acute Myeloblastic Leukemia in Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder in which the blood cells demonstrate aberrant interactions with serum complement. In part, this is due to the absence of the complement regulatory protein, decay accelerating factor (DAF). A small number of patients with PNH have gone on to develop acute nonlymphocytic leukemia, which is thought to arise f...